Hyaluronate inhibition of cell proliferation

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Inhibition of hyaluronate synthesis.

UDP-GlcNAc (UDP-N-acetylglucosamine) and UDP-GlcA (UDP-glucuronic acid) were oxidized by periodate in the ribose ring and utilized as inhibitors for hyaluronate synthase in membrane fractions from the B6 cell line and in cell cultures of B6 cells and human fibrosarcoma HT 1080. Inhibition was irreversible and concentration-dependent and could be prevented in the case of periodate-oxidized UDP-G...

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ژورنال

عنوان ژورنال: Arthritis & Rheumatism

سال: 1987

ISSN: 0004-3591,1529-0131

DOI: 10.1002/art.1780300707